分类
新手都可掌握的蜡烛图分析法

什麼是最低存款金額 Expert Option?

了解更多

An overview of ozanimod as a therapeutic option for adults with moderate-to-severe active ulcerative colitis

Introduction: Ulcerative colitis (UC) is 什麼是最低存款金額 Expert Option? a chronic inflammatory condition of the gastrointestinal tract involving a dysregulated immune response. Sphingosine-1-phosphate (S1P) is involved in immune cell regulation. S1P-receptor modulators, such as ozanimod, inhibit lymphocyte migration and have therapeutic potential in UC.

Areas covered: Ozanimod is the first S1P-receptor modulator approved for the treatment of UC. It acts as a functional antagonist, causing internalization of S1P receptors on T-cells. Lymphocyte egress from lymph nodes is inhibited, and migration to sites of active inflammation is curtailed. There are several S1P-receptor subtypes, present in various organs, which inform understanding of ozanimod's side-effect profile including bradycardia and macular edema. In this review, the authors discuss the mechanism of action, pharmacokinetics, clinical efficacy, and safety profile of ozanimod in the treatment of patients with moderate-to-severe UC.

Expert opinion: The S1P-receptor modulator ozanimod is an oral small molecule with a rapid onset of action and a novel therapeutic mechanism in the treatment of UC. It is an effective treatment both in bio-naïve and bio-exposed patients. Although the safety profile of ozanimod looks favorable, more long-term data are needed. Further studies are required to compare ozanimod to currently available therapies to best define its positioning in UC treatment algorithms.

Keywords: Inflammatory bowel disease; ozanimod; small molecules; sphingosine-1-phosphate receptor modulators; ulcerative colitis.

Similar articles

Choi D, Stewart AP, Bhat S. Choi 什麼是最低存款金額 Expert Option? D, et al. Ann Pharmacother. 2022 May;56(5):592-599. doi: 10.1177/10600280211041907. Epub 2021 Aug 22. Ann Pharmacother. 2022. PMID: 34423657 Review.

Aoun R, Hanauer S. Aoun R, et al. Expert Rev Gastroenterol Hepatol. 2022 May;16(5):411-423. doi: 10.1080/17474124.2022.2065258. Expert Rev Gastroenterol Hepatol. 2022. PMID: 35400292 Review.

Antonelli EK, Del Sordo R, Morelli O, Villanacci V, Bassotti G. Antonelli EK, et al. Drugs Today (Barc). 2022 Jul;58(7):351-367. doi: 10.1358/dot.2022.58.7.3408818. Drugs Today (Barc). 2022. PMID: 35851870 Review.

Argollo M, Furfaro F, Gilardi D, Roda G, Allocca M, Peyrin-Biroulet L, Danese S. Argollo M, et al. Expert Opin Biol Ther. 2020 Apr;20(4):413-420. doi: 10.1080/14712598.2020.1732919. Epub 2020 Feb 25. Expert Opin Biol Ther. 2020. PMID: 32093531 Review.

Sandborn WJ, Feagan BG, Wolf DC, D'Haens G, Vermeire S, Hanauer SB, Ghosh 什麼是最低存款金額 Expert Option? S, Smith H, Cravets M, Frohna PA, Aranda R, Gujrathi S, Olson A; TOUCHSTONE Study Group. Sandborn WJ, et al. N Engl J Med. 2016 May 5;374(18):1754-62. doi: 10.1056/NEJMoa1513248. N Engl J Med. 2016. PMID: 27144850 Clinical Trial.

Fast online trading

ExpertOption is the leader in online trading industry.
We are trusted by more than 70,000,什麼是最低存款金額 Expert Option? 000 clients.

Best Trading Platform

Global trading platform

Company doesn't provide services to citizens and residents of USA, Canada, European Economic Area, Switzerland, Israel, New Zealand, Australia, North Korea, Puerto Rico, Singapore, Russia, Iran and Yemen.

Payment methods

Trading and investing involves significant level of risk and is not suitable and/or appropriate for all clients. Please make sure you carefully consider your investment objectives, level of experience and risk appetite before buying or selling. Buying or selling entails financial risks and could result in a partial or complete loss of your funds, therefore, you should not invest funds you cannot afford to lose. You should be aware of and fully understand all the risks associated with trading and investing, and seek advice from an independent financial advisor if you have any doubts. You are granted limited non-exclusive rights to use the IP contained 什麼是最低存款金額 Expert Option? in this site for personal, non-commercial, non-transferable use only in relation to the services offered on the site.

Microsoft Certified: Azure DevOps Engineer Expert

DevOps engineers are developers or infrastructure administrators who also have subject matter expertise in working with people, processes, and products to enable continuous delivery of value in organizations.

Responsibilities for this role include designing and implementing strategies for collaboration, code, infrastructure, source control, security, compliance, continuous integration, testing, delivery, monitoring, and feedback.

DevOps engineers work on cross-functional teams that 什麼是最低存款金額 Expert Option? include developers, site reliability engineers, and Azure 什麼是最低存款金額 Expert Option? administrators.

Candidates for this certification must have experience with administering and developing in Azure, with strong skills in at least one of these areas. They should be familiar with both Azure DevOps and GitHub.

The English language version of this certification was updated on July 13, 2022. Visit the Exam AZ-400 page to download the study guide.

什麼是最低存款金額 Expert Option?

原色調

深色調

東亞銀行至尊理財

了解更多

東亞銀行批發銀行服務

了解更多

東亞銀行私人銀行服務

了解更多

東亞銀行保險及強積金服務

了解更多

東亞銀行外匯孖展及期權孖展交易服務

了解更多

東亞銀行中國業務

了解更多

東亞銀行海外業務

了解更多

東亞銀行可持續發展

了解更多